We utilize safe and easy-to-produce nano-scale building blocks with unique properties that “self-assemble”, creating durable nano-scale barriers for protection against fouling and corrosion, reducing friction and drag, and eliminating contamination, all in an environmentally-friendly manner. Recent advances in computational power enable us to predict and control processes in complex industrial environments. Our building blocks can be easily applied without line-of-sight application, sophisticated equipment, or special substrate treatments. Our nano-layers “self-clean” and “self-heal” for extended durability. In industrial environments, these innovations reduce downtime and maintenance, improve energy efficiency, and decrease environmental risks.